STORAGE: Store at room temperature away from moisture and sunlight. Access health plan drug formulary information when looking up a particular drug, and save time and effort for you and your patient. You are encouraged to report negative side effects of prescription drugs to the FDA. Theophylline side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. If these symptoms persist or worsen, inform your doctor. The active ingredient in the drug is the compound Doxofylline that is a Xanthine derivative. A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. Drug Name Confusion: Preventing Medication Errors, Congress Passes Pandemic Economic Relief Package, Biden Picks Obamacare Supporter to Head HHS, Health Coverage Takes Big Hit With Job Cuts. Your dose may need to be adjusted. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Many xanthine bronchodilator users experience no, or minor, side effects, particularly if serum theophylline levels are less than 20 mcg/mL. Side Effects and Safety. The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide. Plus, search the MEDLINE database for journal articles. Choose from our complete list of over 1800 insurance plans across all 50 US states. Doctors rarely prescribe theophylline anymore because many people experience significant side effects. Sie werden aber nicht therapeutisch als Entwässerungsmittel eingesetzt. Large amounts of char-broiled foods or a high protein, low carbohydrate diet can affect the action of this medication. Patients will need serum blood levels tested every six to twelve months. The air we breathe in (inhalation) is warmed, humidified, and cleaned by the nose and the lungs. Tell your doctor your complete medical history especially if you are taking medicine (beta-blockers) for high blood pressure. Medscape Reference features 129 medical calculators covering formulas, scales, and classifications. COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. More than 7100 monographs are provided for prescription and over-the-counter drugs, as well as for corresponding brand-name drugs, herbals, and supplements. Do not freeze liquid forms of this medication. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. If these symptoms persist or worsen, inform your doctor. Visit the FDA MedWatch website or call 1-800-FDA-1088. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Requires evaluation of therapeutic blood level to prevent toxicity: Long-term treatment of chronic asthma and COPD unresponsive to other treatment: GI: Nausea, vomiting. Sign Up for MedicineNet Newsletters. Xanthine derivatives have been used in allergic asthma for their bronchodilatory and anti-inflammatory properties; however, these agents have multiple side effects. Common side effects are belching, bloating, stomach discomfort or upset, nausea, vomiting, indigestion, dizziness, and flushing. It is an overdose reaction to the xanthine alkaloid theobromine. Our Drug Interaction Checker provides rapid access to tens of thousands of interactions between brand and generic drugs, over-the-counter drugs, and supplements. Because small amounts of this drug appear in breast milk, consult with your doctor before breast-feeding. The amount found in chocolate is small enough that chocolate can, in general, is safely consumed by humans. More than 1000 clinical procedure articles provide clear, step-by-step instructions and include instructional videos and images to allow clinicians to master the newest techniques or to improve their skills in procedures they have performed previously. Nervousness and insomnia The xanthines, which are purine analogues, are non-selective inhibitors of phosphodiesterase and also antagonists at adenosine receptors. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Adverse/Side Effects. SIDE EFFECTS: Dizziness, headache, lightheadedness, heartburn, stomach pain, loss of appetite, restlessness, nervousness, sleeplessness or increased urination may occur as your body adjusts to the medication. Xanthines can cause a mild diuresis. 7. Theophylline should not be used concurrently with other preparations containing xanthine derivatives. Prophylactic effects of xanthines against bronchoconstriction induced by an aerosol of ovalbumin in sensitized guinea pigs, or by aerosols of leukotriene D4 and platelet-activating factor (PAF) in normal guinea pigs, occurred by a mechanism unrelated to bronchodilation and could not be readily attributed to PDE inhibition or adenosine A1/A2 receptor antagonism. The articles assist in the understanding of the anatomy involved in treating specific conditions and performing procedures. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. They should avoid irritants and drink fluids to help thin secretions. Easily compare tier status for drugs in the same class when considering an alternative drug for your patient. 5 to 10 for COPD, 5 to 15 for asthma and keep under 20, in general. Due to widespread effects, the therapeutic range of xanthine is narrow, making it a merely second-line asthma treatment. Neither at the low nor at the high dosage (2+4 mg/kg), giving plasma concentrations of 8.5±1.4 µg/ml, did enprofylline produce theophylline-like CNS effects, such as restlessness and tremor, but it did exhibit some of the innocuous side effects expected with xanthine derivatives, such as epigastric discomfort and headache. Drug images are also included. Common side effects of xanthines include: Nausea; Vomiting; Diarrhea; Headaches; Irritability; Flushing; Palpitations; Other side effects of xanthines include: Diuresis; Restlessness; Tremor; Insomnia; Possible serious side effects of xanthines include: Seizures; Shock; Heart arrhythmias ; Hypotension; Exfoliative dermatitis The therapeutic level is 10-20 micrograms/mL blood; signs of toxicity include tremor, nausea, nervousness, and tachycardia/arrhythmia. Xanthine Derivatives: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference Andjus RK(1), Konjević D, Damjanović I, Gacić Z. CNS stimulation. If stomach upset occurs, it may be taken with food. Xanthine Derivatives. More than 100 anatomy articles feature clinical images and diagrams of the human body's major systems and organs. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert. Terms of Use. Do not "double-up" the dose to catch up. SIDE EFFECTS: Dizziness, headache, lightheadedness, heartburn, stomach pain, loss of appetite, restlessness, nervousness, sleeplessness or increased urination may occur as your body adjusts to the medication. This medication works best if a constant level is maintained in the body. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. Plus, more than 600 drug monographs in our drug reference include integrated dosing calculators. Owing to their ability to relax bronchial muscles, the xanthines are used chiefly in the maintenance treatment of asthma and chronic obstructive pulmonary disease. This website also contains material copyrighted by 3rd parties. Generic Drugs, Are They as Good as Brand-Names? Therapeutic Effects Adverse/Side Effects; Xanthine: theophylline: Avoid caffeine. Inform your doctor if you experience: chest pain, rapid or irregular heartbeat, confusion, severe stomach pain, breathing difficulties. Canadian residents should call their local poison control center directly. Capsules and tablets must be swallowed whole `` double-up '' the dose catch!, chronic bronchitis, chronic bronchitis, and radiographic images of side effects drugs... You will be required to enter your username and password the next time you visit of. 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